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In one approach, called regional perfusion or isolation perfusion, the blood supply to a part of the body is isolated from the rest of the circulation.

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The blood in that part of the body is pumped into a heating device and then pumped back into the area to heat it. Chemotherapy can be pumped in at the same time. This technique is being studied as treatment for certain cancers in the arms or legs, such as sarcomas and melanomas. Another hyperthermia technique can be used along with surgery to treat cancers in the peritoneum. During surgery, heated chemotherapy drugs are circulated through the peritoneal cavity. This is called continuous hyperthermic peritoneal perfusion, also known as hyperthermic intraperitoneal chemotherapy. In studies, this has seemed helpful in treating certain types of cancer, but it isn’t yet clear if it is better than other types of treatments.

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